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Gleneagle Clinic

Greygates | Stillorgan Road | Blackrock | Dublin

  • Surgery: (01) 288 1425
  • Out of hours: (01) 453 9333

Low Dose Naltrexone (LDN)

LDN is a game changing medication that evolved from the treatment of opiate-addiction. It is now improving the lives of patients suffering with cancer, Crohn's Disease, Rheumatroid Arthritis, and Multiple Sclerosis. It is also proving very effective in the treatment of chronic pain.

LDN is a very interesting medication that started out in the treatment of opiate-addiction a long time ago. This was at a dose of 50mg daily. It was found that at a very low dose (less than 4.5mg daily - just under 10%), it had significant pain and immunomodulatory effects. This is most likely because it blocks endogenous opioids, leading to a reflex increase in endorphins that cause a "feel-good" effect and hence cause significant pain relief.

This effect also has the benefit of modifying the immune system to prevent over and under-immunoactivity. Hence, this drug is widely in use in chronic pain management and as an adjunct in some forms of cancer therapy.

It is useful in many conditions where the immune system is overactive, including Crohn's Disease, Rheumatoid Arthritis and Multiple Sclerosis. It is now off-patent meaning that it is relatively inexpensive and practical for long-term use. We at the Gleneagle clinic are expert at the appropriate prescription of LDN. We are familiar with the indications, any contra-indications and any side-effects of this safe and effective medication.

Dr Edmond O'Flaherty is one of the leading pioneers in the use of LDN in Ireland. He was recognised by Norwegian Television in 2013 with a documentary that acknowledged him as one of the leading experts on the medication in Europe. He has shared his expertise with Dr Andrew O'Flaherty and both are now highly skilled in this emerging field.

Learn more about Low Dose Naltraxone.